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Hepatic biotransformation of MLN8054 was studied in vitro utilizing human liver S9 fractions (Info on file, Millennium). Glucuronidation with the carboxylate moiety of MLN8054 to an acyl glucuronide was the predominant system of biotransformation, Hydroxylation in the azepine moiety of MLN8054 was the foremost section one biotransformation pathway.

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